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5'-O-DMT-N4-Ac-dC CAS 100898-63-3 | Protected Nucleoside for Oligonucleotide and dod-DNA Production | |
5'-O-DMT-N4-Ac-dC CAS:100898-63-3 is a modified deoxynucleoside derivative widely used as a phosphoramidite monomer in DNA synthesis and molecular biology research. Its structure integrates three essential features: N4-Acetyl protection: Prevents unwanted side reactions during solid-phase oligonucleotide synthesis, ensuring high coupling efficiency and selectivity. 5'-O-Dimethoxytrityl (DMTr) group: An acid-labile protecting group that allows efficient deprotection and purification in automated DNA synthesis. Deoxycytidine core: Serves as a fundamental DNA building block and precursor for generating various functionalized nucleosides. Key Applications Oligonucleotide Synthesis: Essential for preparing research-grade and therapeutic oligonucleotides, supporting studies in gene regulation and nucleic acid drug development. Antiviral and Anticancer Research: Used as a precursor for synthesizing modified nucleosides with potential antiviral and anticancer properties. dod-DNA Production: Plays a crucial role in the synthesis of dodecyl phosphoramidite, a key precursor for dod-DNA. Biochemical Studies: Applied in investigations of DNA–protein interactions and in the development of DNA-based nanomaterials. In summary, 5'-O-DMT-N4-Ac-dC (CAS: 100898-63-3) is not only a critical building block in DNA synthesis but also an important compound for advancing therapeutic research and nanobiotechnology. | |
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2025-09-06 (1.002 sec)